Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing

Small interfering RNA (siRNA) has found many applications in tissue regeneration and disease therapeutics. Effective and localized siRNA delivery remains challenging, reducing its therapeutic potential. Here, we report a strategy to control and prolong siRNA release by directly tethering transfectio...

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Detalles Bibliográficos
Autores principales: Nguyen, Minh Khanh, Huynh, Cong Truc, Gilewski, Alex, Wilner, Samantha E., Maier, Keith E., Kwon, Nicholas, Levy, Mathew, Alsberg, Eben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713499/
https://www.ncbi.nlm.nih.gov/pubmed/31489374
http://dx.doi.org/10.1126/sciadv.aax0801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713499/
https://www.ncbi.nlm.nih.gov/pubmed/31489374
http://dx.doi.org/10.1126/sciadv.aax0801

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