Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they coordinate to determine longevity and if they act via separable mechanisms is unclear. Here, we show that neuronal AMPK is essential for lifespan extension...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Lanjuin, Anne, Chowdhury, Suvagata Roy, Mistry, Meeta, Silva-García, Carlos G, Weir, Heather J, Lee, Chia-Lin, Escoubas, Caroline C, Tabakovic, Emina, Mair, William B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713509/
https://www.ncbi.nlm.nih.gov/pubmed/31411562
http://dx.doi.org/10.7554/eLife.49158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713509/
https://www.ncbi.nlm.nih.gov/pubmed/31411562
http://dx.doi.org/10.7554/eLife.49158

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