Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection

Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of severe diarrheal illness in low- and middle-income countries. The live-attenuated ACE527 ETEC vaccine, adjuvanted with double mutant heat-labile toxin (dmLT), affords clear but partial protection against ETEC challenge in human...

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Detalles Bibliográficos
Autores principales: Chakraborty, Subhra, Randall, Arlo, Vickers, Tim J., Molina, Doug, Harro, Clayton D., DeNearing, Barbara, Brubaker, Jessica, Sack, David A., Bourgeois, A. Louis, Felgner, Philip L., Liang, Xiaowu, Mani, Sachin, Wenzel, Heather, Townsend, R. Reid, Gilmore, Petra E., Darsley, Michael J., Rasko, David A., Fleckenstein, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713706/
https://www.ncbi.nlm.nih.gov/pubmed/31482013
http://dx.doi.org/10.1038/s41541-019-0131-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713706/
https://www.ncbi.nlm.nih.gov/pubmed/31482013
http://dx.doi.org/10.1038/s41541-019-0131-7

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