Metoclopramide-Induced Acute Dystonic Reactions May Be Associated With the CYP2D6 Poor Metabolizer Status and Pregnancy-Related Hormonal Changes

We report two cases of metoclopramide-induced acute dystonia in pregnant women and consider the role of genetic variation in the pathogenesis of the adverse effect. By whole-gene sequencing, we found that both women were CYP2D6 poor metabolizers. We theorize that CYP2D6 governs the risk of metoclopr...

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Detalles Bibliográficos
Autores principales: Chua, Eng Wee, Harger, Simon P., Kennedy, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713716/
https://www.ncbi.nlm.nih.gov/pubmed/31507424
http://dx.doi.org/10.3389/fphar.2019.00931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713716/
https://www.ncbi.nlm.nih.gov/pubmed/31507424
http://dx.doi.org/10.3389/fphar.2019.00931

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