Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Germinal center (GC) B cells at viral replication sites acquire specificity to poorly immunogenic but conserved influenza hemagglutinin (HA) epitopes. Here, high-throughput epitope mapping of local GC B cells is used to identify conserved HA epitope selecting cross-reactive antibodies that mediate h...

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Detalles Bibliográficos
Autores principales: Adachi, Yu, Tonouchi, Keisuke, Nithichanon, Arnone, Kuraoka, Masayuki, Watanabe, Akiko, Shinnakasu, Ryo, Asanuma, Hideki, Ainai, Akira, Ohmi, Yusuke, Yamamoto, Takuya, Ishii, Ken J., Hasegawa, Hideki, Takeyama, Haruko, Lertmemongkolchai, Ganjana, Kurosaki, Tomohiro, Ato, Manabu, Kelsoe, Garnett, Takahashi, Yoshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713747/
https://www.ncbi.nlm.nih.gov/pubmed/31462639
http://dx.doi.org/10.1038/s41467-019-11821-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713747/
https://www.ncbi.nlm.nih.gov/pubmed/31462639
http://dx.doi.org/10.1038/s41467-019-11821-6

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