Cargando…

Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Germinal center (GC) B cells at viral replication sites acquire specificity to poorly immunogenic but conserved influenza hemagglutinin (HA) epitopes. Here, high-throughput epitope mapping of local GC B cells is used to identify conserved HA epitope selecting cross-reactive antibodies that mediate h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adachi, Yu, Tonouchi, Keisuke, Nithichanon, Arnone, Kuraoka, Masayuki, Watanabe, Akiko, Shinnakasu, Ryo, Asanuma, Hideki, Ainai, Akira, Ohmi, Yusuke, Yamamoto, Takuya, Ishii, Ken J., Hasegawa, Hideki, Takeyama, Haruko, Lertmemongkolchai, Ganjana, Kurosaki, Tomohiro, Ato, Manabu, Kelsoe, Garnett, Takahashi, Yoshimasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713747/ https://www.ncbi.nlm.nih.gov/pubmed/31462639 http://dx.doi.org/10.1038/s41467-019-11821-6

Ejemplares similares

Diagnosis of NTM active infection in lymphadenopathy patients with anti-interferon-gamma auto-antibody using inhibitory ELISA vs. indirect ELISA
por: Nithichanon, Arnone, et al.
Publicado: (2020)

Evaluation of plasma anti-GPL-core IgA and IgG for diagnosis of disseminated non-tuberculous mycobacteria infection
por: Nithichanon, Arnone, et al.
Publicado: (2020)

Glibenclamide impairs responses of neutrophils against Burkholderia pseudomallei by reduction of intracellular glutathione
por: Kewcharoenwong, Chidchamai, et al.
Publicado: (2016)

Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes
por: Nithichanon, Arnone, et al.
Publicado: (2020)

Evaluating anti-GPL-core IgA as a diagnostic tool for non-tuberculous mycobacterial infections in Thai patients with high antibody background
por: Manbenmad, Varis, et al.
Publicado: (2023)

A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines
por: Wada, Yamato, et al.
Publicado: (2017)

Publisher Correction: A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines
por: Wada, Yamato, et al.
Publicado: (2019)

Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes
por: Saenwongsa, Wipawee, et al.
Publicado: (2020)

Intravenous Cyclophosphamide Therapy for Anti-IFN-Gamma Autoantibody-Associated Mycobacterium abscessus Infection
por: Chetchotisakd, Ploenchan, et al.
Publicado: (2018)

Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope
por: Tonouchi, Keisuke, et al.
Publicado: (2023)

Vitamin D3 regulates PM-driven primary human neutrophil inflammatory responses
por: Kewcharoenwong, Chidchamai, et al.
Publicado: (2023)

Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei
por: Kessler, Bianca, et al.
Publicado: (2017)

Efficient protection of mice from influenza A/H1N1pdm09 virus challenge infection via high avidity serum antibodies induced by booster immunizations with inactivated whole virus vaccine
por: Sato, Kayoko, et al.
Publicado: (2019)

Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies
por: Bajic, Goran, et al.
Publicado: (2019)

Acinetobacter nosocomialis Causes as Severe Disease as Acinetobacter baumannii in Northeast Thailand: Underestimated Role of A. nosocomialis in Infection
por: Nithichanon, Arnone, et al.
Publicado: (2022)

Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection
por: Kewcharoenwong, Chidchamai, et al.
Publicado: (2013)

A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface
por: McCarthy, Kevin R., et al.
Publicado: (2021)

Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes
por: Nithichanon, Arnone, et al.
Publicado: (2018)

Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial
por: Kewcharoenwong, Chidchamai, et al.
Publicado: (2022)

Systematic Mutagenesis of Genes Encoding Predicted Autotransported Proteins of Burkholderia pseudomallei Identifies Factors Mediating Virulence in Mice, Net Intracellular Replication and a Novel Protein Conferring Serum Resistance
por: Adler, Natalie R. Lazar, et al.
Publicado: (2015)

BPSL1626: Reverse and Structural Vaccinology Reveal a Novel Candidate for Vaccine Design against Burkholderia pseudomallei
por: Capelli, Riccardo, et al.
Publicado: (2018)

An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic shock syndrome
por: Matsumura, Takayuki, et al.
Publicado: (2020)

Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
por: Yeh, Chen-Hao, et al.
Publicado: (2018)

Distinct germinal center selection at local sites shapes memory B cell response to viral escape
por: Adachi, Yu, et al.
Publicado: (2015)

Sequence- and Structure-Based Immunoreactive Epitope Discovery for Burkholderia pseudomallei Flagellin
por: Nithichanon, Arnone, et al.
Publicado: (2015)

Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in Japan
por: Ainai, Akira, et al.
Publicado: (2015)

Generation of High Quality Memory B Cells
por: Inoue, Takeshi, et al.
Publicado: (2022)

Conserved cryptic recombination signals in Vκ gene segments are cleaved in small pre-B cells
por: Lieberman, Anne E, et al.
Publicado: (2009)

Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3(+)CD4(+) T Cells
por: Iwabuchi, Ryutaro, et al.
Publicado: (2018)

Bystander T cells in human immune responses to dengue antigens
por: Suwannasaen, Duangchan, et al.
Publicado: (2010)

CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes
por: Onodera, Taishi, et al.
Publicado: (2023)

Broad Cross-Reactive Epitopes of the H5N1 Influenza Virus Identified by Murine Antibodies against the A/Vietnam/1194/2004 Hemagglutinin
por: Kobayashi-Ishihara, Mie, et al.
Publicado: (2014)

Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage
por: Rinchai, Darawan, et al.
Publicado: (2016)

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection
por: Takahashi, Yoshimasa, et al.
Publicado: (1998)

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization
por: Kewcharoenwong, Chidchamai, et al.
Publicado: (2018)

Site-specific gene expression analysis using an automated tissue micro-dissection punching system
por: Yoda, Takuya, et al.
Publicado: (2017)

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help
por: Inoue, Takeshi, et al.
Publicado: (2017)

Development of an Open-Heart Intraoperative Risk Scoring Model for Predicting a Prolonged Intensive Care Unit Stay
por: Tribuddharat, Sirirat, et al.
Publicado: (2014)

Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design
por: Finney, Joel, et al.
Publicado: (2018)

Pulsatile thrombus evacuation from the false lumen of an occluded carotid artery in acute aortic dissection
por: Sasaki, Hideki, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lbj5f82l6gtdcqvvsgd8d4veur