Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

Telomeres are considered potential anti-cancer targets. Most studies have focused on telomerase inhibition, but this strategy has largely failed in clinical trials. Direct disruption of the shelterin complex through TRF1 inhibition can block tumorigenesis in cancer mouse models by a mechanism that i...

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Detalles Bibliográficos
Autores principales: Bejarano, Leire, Louzame, Jessica, Montero, Juán José, Megías, Diego, Flores, Juana M., Blasco, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713815/
https://www.ncbi.nlm.nih.gov/pubmed/31446222
http://dx.doi.org/10.1016/j.isci.2019.08.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713815/
https://www.ncbi.nlm.nih.gov/pubmed/31446222
http://dx.doi.org/10.1016/j.isci.2019.08.012

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