Improving the solubility, activity, and stability of reteplase using in silico design of new variants

Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and E. coli expressibility. Despite these outstanding features, it demonstrates reduced fibri...

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Detalles Bibliográficos
Autores principales: Ghaheh, Hooria Seyedhosseini, Ganjalikhany, Mohamad Reza, Yaghmaei, Parichehreh, Pourfarzam, Morteza, Mir Mohammad Sadeghi, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714118/
https://www.ncbi.nlm.nih.gov/pubmed/31516513
http://dx.doi.org/10.4103/1735-5362.263560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714118/
https://www.ncbi.nlm.nih.gov/pubmed/31516513
http://dx.doi.org/10.4103/1735-5362.263560

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