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Polycystin‐1 affects cancer cell behaviour and interacts with mTOR and Jak signalling pathways in cancer cell lines

Polycystic Kidney Disease (PKD), which is attributable to mutations in the PKD1 and PKD2 genes encoding polycystin‐1 (PC1) and polycystin‐2 (PC2) respectively, shares common cellular defects with cancer, such as uncontrolled cell proliferation, abnormal differentiation and increased apoptosis. Inter...

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Detalles Bibliográficos
Autores principales: Papavassiliou, Kostas A., Zoi, Ilianna, Gargalionis, Antonios N., Koutsilieris, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714176/
https://www.ncbi.nlm.nih.gov/pubmed/31251475
http://dx.doi.org/10.1111/jcmm.14506