CRISPR/dCas9‐mediated activation of multiple endogenous target genes directly converts human foreskin fibroblasts into Leydig‐like cells

Recently, Leydig cell (LC) transplantation has been revealed as a promising strategy for treating male hypogonadism; however, the key problem restricting the application of LC transplantation is a severe lack of seed cells. It seems that targeted activation of endogenous genes may provide a potentia...

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Detalles Bibliográficos
Autores principales: Huang, Hua, Zou, Xiangyu, Zhong, Liang, Hou, Yanping, Zhou, Jin, Zhang, Zhiyuan, Xing, Xiaoyu, Sun, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714237/
https://www.ncbi.nlm.nih.gov/pubmed/31264792
http://dx.doi.org/10.1111/jcmm.14470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714237/
https://www.ncbi.nlm.nih.gov/pubmed/31264792
http://dx.doi.org/10.1111/jcmm.14470

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