Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex

Nsun5 gene, encoding a cytosine-5 RNA methyltransferase, is deleted in about 95% patients with Williams-Beuren syndrome (WBS). WBS is a neurodevelopmental disorder and characterized by cognitive disorder. We generated single-gene Nsun5 knockout (Nsun5-KO) mice and reported that the Nsun5 deletion le...

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Detalles Bibliográficos
Autores principales: Chen, Peipei, Zhang, Tingting, Yuan, Zihao, Shen, Bin, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714381/
https://www.ncbi.nlm.nih.gov/pubmed/31462248
http://dx.doi.org/10.1186/s13041-019-0496-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714381/
https://www.ncbi.nlm.nih.gov/pubmed/31462248
http://dx.doi.org/10.1186/s13041-019-0496-6

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