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Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease. Here, we investigate whether pharmacological manipulation of the str...
Autores principales: | Gonçalves, Ana Cláudia, Towers, Emily R., Haq, Naila, Porco, John A., Pelletier, Jerry, Dawson, Sally J., Gale, Jonathan E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715625/ https://www.ncbi.nlm.nih.gov/pubmed/31467369 http://dx.doi.org/10.1038/s41598-019-48393-w |
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