A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells

The cell-cell adhesion protein E-cadherin (CDH1) is a tumor suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer (DGC) and lobular breast cancer (LBC). In addition, germline mutations in CDH1...

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Detalles Bibliográficos
Autores principales: Beetham, Henry, Chen, Augustine, Telford, Bryony J., Single, Andrew, Jarman, Kate E., Lackovic, Kurt, Luxenburger, Andreas, Guilford, Parry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715681/
https://www.ncbi.nlm.nih.gov/pubmed/31467357
http://dx.doi.org/10.1038/s41598-019-48929-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715681/
https://www.ncbi.nlm.nih.gov/pubmed/31467357
http://dx.doi.org/10.1038/s41598-019-48929-0

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