Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABA(A) Receptors

Hyperekplexia disease is usually caused by naturally occurring point mutations in glycine receptors (GlyRs). However, the γ-aminobutyric acid type A receptor (GABA(A)R) seems to be also involved regarding the therapeutic basis for hyperekplexia using benzodiazepines, which target GABA(A)Rs but not G...

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Detalles Bibliográficos
Autores principales: Zou, Guichang, Chen, Qi, Chen, Kai, Zuo, Xin, Ge, Yushu, Hou, Yiwen, Pan, Tao, Pan, Huilin, Liu, Dan, Zhang, Li, Xiong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715904/
https://www.ncbi.nlm.nih.gov/pubmed/31450193
http://dx.doi.org/10.1016/j.isci.2019.08.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715904/
https://www.ncbi.nlm.nih.gov/pubmed/31450193
http://dx.doi.org/10.1016/j.isci.2019.08.018

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