Cargando…

Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABA(A) Receptors

Hyperekplexia disease is usually caused by naturally occurring point mutations in glycine receptors (GlyRs). However, the γ-aminobutyric acid type A receptor (GABA(A)R) seems to be also involved regarding the therapeutic basis for hyperekplexia using benzodiazepines, which target GABA(A)Rs but not G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Guichang, Chen, Qi, Chen, Kai, Zuo, Xin, Ge, Yushu, Hou, Yiwen, Pan, Tao, Pan, Huilin, Liu, Dan, Zhang, Li, Xiong, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715904/ https://www.ncbi.nlm.nih.gov/pubmed/31450193 http://dx.doi.org/10.1016/j.isci.2019.08.018

Ejemplares similares

4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors
por: de la Roche, Jeanne, et al.
Publicado: (2012)

GABA fine-tunes the glycine receptor
por: Robinson, Richard
Publicado: (2008)

The cannabinoid dehydroxylcannabidiol suppresses neuropathic pain by upregulating a spinal glycine receptor-mediated compensation mechanism
por: Xia, Jing, et al.
Publicado: (2023)

Cl(−) concentration changes and desensitization of GABA(A) and glycine receptors
por: Karlsson, Urban, et al.
Publicado: (2011)

Structural basis of GABARAP-mediated GABA(A) receptor trafficking and functions on GABAergic synaptic transmission
por: Ye, Jin, et al.
Publicado: (2021)

GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition
por: Murley, Alexander G, et al.
Publicado: (2020)

Localization of Glycine Receptors in the Human Forebrain, Brainstem, and Cervical Spinal Cord: An Immunohistochemical Review
por: Baer, Kristin, et al.
Publicado: (2009)

Brainstem activation of GABA(B) receptors in the nucleus tractus solitarius increases gastric motility
por: Bellusci, Lorenza, et al.
Publicado: (2022)

Golgi Cell-Mediated Activation of Postsynaptic GABA(B) Receptors Induces Disinhibition of the Golgi Cell-Granule Cell Synapse in Rat Cerebellum
por: Brandalise, Federico, et al.
Publicado: (2012)

Structure–Function Relationships of Glycine and GABA(A) Receptors and Their Interplay With the Scaffolding Protein Gephyrin
por: Kasaragod, Vikram B., et al.
Publicado: (2018)

Correction: Golgi Cell-Mediated Activation of Postsynaptic GABA(B) Receptors Induces Disinhibition of the Golgi Cell-Granule Cell Synapse in Rat Cerebellum
por: Brandalise, Federico, et al.
Publicado: (2013)

Generation of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits
por: Dixon, Christine L., et al.
Publicado: (2015)

Reconstitution of GABA, Glycine and Glutamate Transporters
por: Danbolt, Niels Christian, et al.
Publicado: (2021)

Distribution of Glycine/GABA Neurons in the Ventromedial Medulla with Descending Spinal Projections and Evidence for an Ascending Glycine/GABA Projection
por: Hossaini, Mehdi, et al.
Publicado: (2012)

GABA and the GABA(A) Receptor
por: Mihic, S. John, et al.
Publicado: (1997)

Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the hippocampus
por: Takkala, Petri, et al.
Publicado: (2013)

Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition
por: Viho, Eva M G, et al.
Publicado: (2022)

Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat
por: Hildreth, Cara M, et al.
Publicado: (2010)

Activation of Glycine and Extrasynaptic GABA(A) Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis
por: Nguyen, Thi Thanh Hoang, et al.
Publicado: (2013)

Maternal taurine as a modulator of Cl(–) homeostasis as well as of glycine/GABA(A) receptors for neocortical development
por: Furukawa, Tomonori, et al.
Publicado: (2023)

Reduced Expression of GABA(A) Receptor Alpha2 Subunit Is Associated With Disinhibition of DYT-THAP1 Dystonia Patient-Derived Striatal Medium Spiny Neurons
por: Staege, Selma, et al.
Publicado: (2021)

The GABA receptors /
Publicado: (2007)

ON-OFF Interactions in the Retina: Role of Glycine and GABA
por: Popova, Elka
Publicado: (2014)

Positive Modulation of the Glycine Receptor by Means of Glycine Receptor–Binding Aptamers
por: Shalaly, Nancy Dekki, et al.
Publicado: (2015)

Subregion-Specific Modulation of Excitatory Input and Dopaminergic Output in the Striatum by Tonically Activated Glycine and GABA(A) Receptors
por: Adermark, Louise, et al.
Publicado: (2011)

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones
por: James, Owain T, et al.
Publicado: (2014)

Behavioral Sensitization to the Disinhibition Effect of Ethanol Requires the Dopamine/Ecdysone Receptor in Drosophila
por: Aranda, Gissel P., et al.
Publicado: (2017)

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
por: Xiong, Wei, et al.
Publicado: (2012)

Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides
por: Mathavan, Indran, et al.
Publicado: (2014)

Heterogeneous Signaling at GABA and Glycine Co-releasing Terminals
por: Aubrey, Karin R., et al.
Publicado: (2018)

Glycine and Glycine Receptor Signalling in Non-Neuronal Cells
por: den Eynden, Jimmy Van, et al.
Publicado: (2009)

Glycine and GABA(A) receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network
por: Curtin, Paul C. P., et al.
Publicado: (2015)

Mechanisms of GABA(B) receptor enhancement of extrasynaptic GABA(A) receptor currents in cerebellar granule cells
por: Khatri, Shailesh N., et al.
Publicado: (2019)

Glycine receptors and brain development
por: Avila, Ariel, et al.
Publicado: (2013)

New GABA amides activating GABA(A)-receptors
por: Raster, Peter, et al.
Publicado: (2013)

Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β(2) subunit of GABA(A) receptors?
por: Baur, Roland, et al.
Publicado: (2013)

Characterization of the Zebrafish Glycine Receptor Family Reveals Insights Into Glycine Receptor Structure Function and Stoichiometry
por: Low, Sean Eric, et al.
Publicado: (2018)

Escherichia coli hijack Caspr1 receptor to invade cerebral vascular and neuronal hosts
por: Zhao, Wei-Dong, et al.
Publicado: (2018)

Malaria Parasites Hijack Host Receptors From Exosomes to Capture Lipoproteins
por: Iso-o, Naoyuki, et al.
Publicado: (2021)

Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons
por: Anderson, Wayne B, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_hs4dc2qq0nb1eguce7r772t94c