Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease

[Image: see text] Proteinaceous aggregation is a well-known observable in Alzheimer’s disease (AD), but failure and storage of lysosomal bodies within neurons is equally ubiquitous and actually precedes bulk accumulation of extracellular amyloid plaque. In fact, AD shares many similarities with cert...

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Detalles Bibliográficos
Autores principales: Lambeth, Tyler R., Riggs, Dylan L., Talbert, Lance E., Tang, Jin, Coburn, Emily, Kang, Amrik S., Noll, Jessica, Augello, Catherine, Ford, Byron D., Julian, Ryan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716341/
https://www.ncbi.nlm.nih.gov/pubmed/31482121
http://dx.doi.org/10.1021/acscentsci.9b00369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716341/
https://www.ncbi.nlm.nih.gov/pubmed/31482121
http://dx.doi.org/10.1021/acscentsci.9b00369

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