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Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease
[Image: see text] Proteinaceous aggregation is a well-known observable in Alzheimer’s disease (AD), but failure and storage of lysosomal bodies within neurons is equally ubiquitous and actually precedes bulk accumulation of extracellular amyloid plaque. In fact, AD shares many similarities with cert...
Autores principales: | Lambeth, Tyler R., Riggs, Dylan L., Talbert, Lance E., Tang, Jin, Coburn, Emily, Kang, Amrik S., Noll, Jessica, Augello, Catherine, Ford, Byron D., Julian, Ryan R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716341/ https://www.ncbi.nlm.nih.gov/pubmed/31482121 http://dx.doi.org/10.1021/acscentsci.9b00369 |
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