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Predicting Kinase Inhibitor Resistance: Physics-Based and Data-Driven Approaches

[Image: see text] Resistance to small molecule drugs often emerges in cancer cells, viruses, and bacteria as a result of the evolutionary pressure exerted by the therapy. Protein mutations that directly impair drug binding are frequently involved in resistance, and the ability to anticipate these mu...

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Detalles Bibliográficos
Autores principales: Aldeghi, Matteo, Gapsys, Vytautas, de Groot, Bert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716344/
https://www.ncbi.nlm.nih.gov/pubmed/31482130
http://dx.doi.org/10.1021/acscentsci.9b00590