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Predicting Kinase Inhibitor Resistance: Physics-Based and Data-Driven Approaches
[Image: see text] Resistance to small molecule drugs often emerges in cancer cells, viruses, and bacteria as a result of the evolutionary pressure exerted by the therapy. Protein mutations that directly impair drug binding are frequently involved in resistance, and the ability to anticipate these mu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716344/ https://www.ncbi.nlm.nih.gov/pubmed/31482130 http://dx.doi.org/10.1021/acscentsci.9b00590 |