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DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis

BACKGROUND: Recent studies have highlighted the contribution of senescent mesenchymal and epithelial cells in Idiopathic Pulmonary Fibrosis (IPF), but little is known regarding the molecular mechanisms that regulate the accumulation of senescent cells in this disease. Therefore, we addressed the hyp...

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Detalles Bibliográficos
Autores principales: Habiel, David M., Hohmann, Miriam S., Espindola, Milena S., Coelho, Ana Lucia, Jones, Isabelle, Jones, Heather, Carnibella, Richard, Pinar, Isaac, Werdiger, Freda, Hogaboam, Cory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716822/
https://www.ncbi.nlm.nih.gov/pubmed/31464599
http://dx.doi.org/10.1186/s12890-019-0922-7