An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

BACKGROUND: Disturbances in clock genes affect almost all patients with Alzheimer’s disease (AD), as evidenced by their altered sleep/wake cycle, thermoregulation, and exacerbation of cognitive impairment. As microglia-mediated neuroinflammation proved to be a driver of AD rather than a result of th...

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Detalles Bibliográficos
Autores principales: Ni, Junjun, Wu, Zhou, Meng, Jie, Saito, Takashi, Saido, Takaomi C., Qing, Hong, Nakanishi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716829/
https://www.ncbi.nlm.nih.gov/pubmed/31470863
http://dx.doi.org/10.1186/s12974-019-1562-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716829/
https://www.ncbi.nlm.nih.gov/pubmed/31470863
http://dx.doi.org/10.1186/s12974-019-1562-9

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