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An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

BACKGROUND: Disturbances in clock genes affect almost all patients with Alzheimer’s disease (AD), as evidenced by their altered sleep/wake cycle, thermoregulation, and exacerbation of cognitive impairment. As microglia-mediated neuroinflammation proved to be a driver of AD rather than a result of th...

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Detalles Bibliográficos
Autores principales:	Ni, Junjun, Wu, Zhou, Meng, Jie, Saito, Takashi, Saido, Takaomi C., Qing, Hong, Nakanishi, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716829/ https://www.ncbi.nlm.nih.gov/pubmed/31470863 http://dx.doi.org/10.1186/s12974-019-1562-9

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