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Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway

BACKGROUND: Ovarian carcinomas are the deadliest gynecological malignancies owing to their high rate of recurrence and high resistance to platinum-based chemotherapy. Recent studies have shown platinum-dependent enrichment of ovarian tumors with side population as well as cancer stem cells, which ar...

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Detalles Bibliográficos
Autores principales: Islam, Syed S., Aboussekhra, Abdelilah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716935/
https://www.ncbi.nlm.nih.gov/pubmed/31470883
http://dx.doi.org/10.1186/s13046-019-1360-3