Rescue of M-cone Function in Aged Opn1mw(−/−) Mice, a Model for Late-Stage Blue Cone Monochromacy

PURPOSE: Previously we showed that AAV5-mediated expression of either human M- or L-opsin promoted regrowth of cone outer segments and rescued M-cone function in the treated M-opsin knockout (Opn1mw(−/−)) dorsal retina. In this study, we determined cone viability and window of treatability in aged O...

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Detalles Bibliográficos
Autores principales: Deng, Wen-Tao, Li, Jie, Zhu, Ping, Freedman, Beau, Smith, W. Clay, Baehr, Wolfgang, Hauswirth, William W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716949/
https://www.ncbi.nlm.nih.gov/pubmed/31469404
http://dx.doi.org/10.1167/iovs.19-27079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716949/
https://www.ncbi.nlm.nih.gov/pubmed/31469404
http://dx.doi.org/10.1167/iovs.19-27079

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