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Rescue of M-cone Function in Aged Opn1mw(−/−) Mice, a Model for Late-Stage Blue Cone Monochromacy
PURPOSE: Previously we showed that AAV5-mediated expression of either human M- or L-opsin promoted regrowth of cone outer segments and rescued M-cone function in the treated M-opsin knockout (Opn1mw(−/−)) dorsal retina. In this study, we determined cone viability and window of treatability in aged O...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Association for Research in Vision and Ophthalmology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716949/ https://www.ncbi.nlm.nih.gov/pubmed/31469404 http://dx.doi.org/10.1167/iovs.19-27079 |