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Broken force dispersal network in tip-links by the mutations at the Ca(2+)-binding residues induces hearing-loss
Tip-link as force-sensor in hearing conveys the mechanical force originating from sound to ion-channels while maintaining the integrity of the entire sensory assembly in the inner ear. This delicate balance between structure and function of tip-links is regulated by Ca(2+)-ions present in endolymph....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717114/ https://www.ncbi.nlm.nih.gov/pubmed/31399498 http://dx.doi.org/10.1042/BCJ20190453 |