iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incomple...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Shuo, Wu, Jiale, Zhong, Shan, Li, Yuntong, Zhang, Ping, Ma, Jingyi, Ren, Jingshan, Tan, Yun, Wang, Yunhao, Au, Kin Fai, Siebold, Christian, Bond, Gareth L., Chen, Zhu, Lu, Min, Jones, E. Yvonne, Lu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717262/
https://www.ncbi.nlm.nih.gov/pubmed/31395738
http://dx.doi.org/10.1073/pnas.1909393116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717262/
https://www.ncbi.nlm.nih.gov/pubmed/31395738
http://dx.doi.org/10.1073/pnas.1909393116

Ejemplares similares