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ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
Although KRAS and TP53 mutations are major drivers of pancreatic ductal adenocarcinoma (PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its effector AMAP1 are often overexpressed in different cancers and regulate the intracellular dynamics of integrins and E-cadher...
Autores principales: | Hashimoto, Shigeru, Furukawa, Shotaro, Hashimoto, Ari, Tsutaho, Akio, Fukao, Akira, Sakamura, Yurika, Parajuli, Gyanu, Onodera, Yasuhito, Otsuka, Yutaro, Handa, Haruka, Oikawa, Tsukasa, Hata, Soichiro, Nishikawa, Yoshihiro, Mizukami, Yusuke, Kodama, Yuzo, Murakami, Masaaki, Fujiwara, Toshinobu, Hirano, Satoshi, Sabe, Hisataka |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717289/ https://www.ncbi.nlm.nih.gov/pubmed/31399545 http://dx.doi.org/10.1073/pnas.1901765116 |
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