MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers

Defects in DNA repair give rise to genomic instability, leading to neoplasia. Cancer cells defective in one DNA repair pathway can become reliant on remaining repair pathways for survival and proliferation. This attribute of cancer cells can be exploited therapeutically, by inhibiting the remaining...

Descripción completa

Detalles Bibliográficos
Autores principales: Srinivasan, Gayathri, Williamson, Elizabeth A., Kong, Kimi, Jaiswal, Aruna S., Huang, Guangcun, Kim, Hyun-Suk, Schärer, Orlando, Zhao, Weixing, Burma, Sandeep, Sung, Patrick, Hromas, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717293/
https://www.ncbi.nlm.nih.gov/pubmed/31395736
http://dx.doi.org/10.1073/pnas.1903150116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717293/
https://www.ncbi.nlm.nih.gov/pubmed/31395736
http://dx.doi.org/10.1073/pnas.1903150116

Ejemplares similares