Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis

Unfolded protein response (UPR) of the endoplasmic reticulum (UPR(ER)) helps maintain proteostasis in the cell. The ability to mount an effective UPR(ER) to external stress (iUPR(ER)) decreases with age and is linked to the pathophysiology of multiple age-related disorders. Here, we show that a tran...

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Detalles Bibliográficos
Autores principales: Matai, Latika, Sarkar, Gautam Chandra, Chamoli, Manish, Malik, Yasir, Kumar, Shashi Shekhar, Rautela, Umanshi, Jana, Nihar Ranjan, Chakraborty, Kausik, Mukhopadhyay, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717303/
https://www.ncbi.nlm.nih.gov/pubmed/31413197
http://dx.doi.org/10.1073/pnas.1900055116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717303/
https://www.ncbi.nlm.nih.gov/pubmed/31413197
http://dx.doi.org/10.1073/pnas.1900055116

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