Cargando…
Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis
Unfolded protein response (UPR) of the endoplasmic reticulum (UPR(ER)) helps maintain proteostasis in the cell. The ability to mount an effective UPR(ER) to external stress (iUPR(ER)) decreases with age and is linked to the pathophysiology of multiple age-related disorders. Here, we show that a tran...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717303/ https://www.ncbi.nlm.nih.gov/pubmed/31413197 http://dx.doi.org/10.1073/pnas.1900055116 |