Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses

BACKGROUND: Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the cure rates for AML patients remain low, and the notorious adverse effects of chemotherapeutic drugs drastically reduce the life quality of patients. Penfluridol, a long-acting oral antipsychotic drug, has an out...

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Detalles Bibliográficos
Autores principales: Wu, Szu-Yuan, Wen, Yu-Ching, Ku, Chia-Chi, Yang, Yi-Chieh, Chow, Jyh-Ming, Yang, Shun-Fa, Lee, Wei-Jiunn, Chien, Ming-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717358/
https://www.ncbi.nlm.nih.gov/pubmed/31470848
http://dx.doi.org/10.1186/s12929-019-0557-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717358/
https://www.ncbi.nlm.nih.gov/pubmed/31470848
http://dx.doi.org/10.1186/s12929-019-0557-2

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