Cargando…

The effect of A1 adenosine receptor in diabetic megalin loss with caspase-1/IL18 signaling

PURPOSE: In our previous study, exacerbation of albuminuria was observed in A1 adenosine receptor knockout (A1AR(−/-)) mice with diabetic nephropathy (DN), but the mechanism was unclear. Here, we investigated the relationship of megalin loss and albuminuria, to identify the protective effect of A1AR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Dongli, Shi, Xiaoxiao, Zhao, Yumo, Peng, Xiaoyan, Zou, Linfeng, Xu, Lubin, Ma, Ying, Wen, Yubin, Faulhaber-Walter, Robert, Chen, Limeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717852/ https://www.ncbi.nlm.nih.gov/pubmed/31695457 http://dx.doi.org/10.2147/DMSO.S215531

Ejemplares similares

The Effect of A1 Adenosine Receptor in Diabetic Megalin Loss with Caspase-1/IL18 Signaling [Corrigendum]
Publicado: (2020)

Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment
por: Tian, Dongli, et al.
Publicado: (2021)

Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome
por: Wang, Jing, et al.
Publicado: (2017)

Adipokines and central control in adenosine A1 receptor dependent glucose metabolism
por: Faulhaber-Walter, Robert
Publicado: (2012)

Podocyte Density and Albuminuria in Aging Diabetic Ins2± Mice with or Without Adenosine A1 Receptor Signaling
por: Faulhaber-Walter, Robert, et al.
Publicado: (2020)

Blockade of the Adenosine A(3) Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats
por: Garrido, Wallys, et al.
Publicado: (2019)

Caspase-1 Abrogates the Salutary Effects of Hypertrophic Preconditioning in Pressure Overload Hearts via IL-1β and IL-18
por: Dai, Fangjie, et al.
Publicado: (2021)

Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
por: Vegt, Erik, et al.
Publicado: (2010)

Neuronal megalin mediates synaptic plasticity—a novel mechanism underlying intellectual disabilities in megalin gene pathologies
por: Gomes, João R, et al.
Publicado: (2020)

Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release
por: Tong, Lei, et al.
Publicado: (2019)

Megalin Orchestrates FcRn Endocytosis and Trafficking
por: Dahlke, Eileen, et al.
Publicado: (2022)

Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study
por: Shoji, Satoshi, et al.
Publicado: (2019)

HIV replication is associated to inflammasomes activation, IL-1β, IL-18 and caspase-1 expression in GALT and peripheral blood
por: Feria, Manuel Gerónimo, et al.
Publicado: (2018)

Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin
por: Bartolome, Fernando, et al.
Publicado: (2017)

LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin
por: Zhou, Yao, et al.
Publicado: (2022)

Lack of megalin expression in adult human terminal ileum suggests megalin‐independent cubilin/amnionless activity during vitamin B(12) absorption
por: Jensen, Louise L., et al.
Publicado: (2014)

Caspase-1: is IL-1 just the tip of the ICEberg?
por: Denes, A, et al.
Publicado: (2012)

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways
por: Li, Ya-feng, et al.
Publicado: (2017)

Mycobacterium tuberculosis Infection of Dendritic Cells Leads to Partially Caspase-1/11-Independent IL-1β and IL-18 Secretion but Not to Pyroptosis
por: Abdalla, Hana, et al.
Publicado: (2012)

Microalbuminuria in Type 1 Diabetes Is Associated With Enhanced Excretion of the Endocytic Multiligand Receptors Megalin and Cubilin
por: Thrailkill, Kathryn M., et al.
Publicado: (2009)

Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes
por: Gravotta, Diego, et al.
Publicado: (2019)

Impaired Glucose Tolerance in the Absence of Adenosine A1 Receptor Signaling
por: Faulhaber-Walter, Robert, et al.
Publicado: (2011)

Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
por: Sun, Jia, et al.
Publicado: (2017)

Megalin-Mediated Trafficking of Mitochondrial Intracrines: Relevance to Signaling and Metabolism
por: Sheikh-Hamad, David, et al.
Publicado: (2021)

It is Good to Recycle: Bringing Megalin Back to the Membrane to Stop Proteinuria
por: Hall, Andrew M, et al.
Publicado: (2022)

Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome
por: Sandoval, Lisette, et al.
Publicado: (2022)

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18
por: Wang, Jinyong, et al.
Publicado: (2018)

AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1β, and IL-18
por: Zhen, Junhui, et al.
Publicado: (2014)

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease
por: Kip, E, et al.
Publicado: (2017)

Continuous hypergammaglobulinemia and proteinuria after the recovery of the visceral Leishmaniasis: a case report
por: Zou, Linfeng, et al.
Publicado: (2021)

Soluble Megalin is Reduced in Cerebrospinal Fluid Samples of Alzheimer’s Disease Patients
por: Spuch, Carlos, et al.
Publicado: (2015)

Significance of Urinary Full-Length Megalin in Patients with IgA Nephropathy
por: Seki, Takuto, et al.
Publicado: (2014)

Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease
por: Perez-Gomez, Maria V, et al.
Publicado: (2020)

Megalin: a Novel Determinant of Renin-Angiotensin System Activity in the Kidney?
por: Sun, Yuan, et al.
Publicado: (2020)

Caspase-1 and IL-1β Processing in a Teleost Fish
por: Reis, Marta I. R., et al.
Publicado: (2012)

Role of the Inflammasome-Caspase1/11-IL-1/18 Axis in Cigarette Smoke Driven Airway Inflammation: An Insight into the Pathogenesis of COPD
por: Eltom, Suffwan, et al.
Publicado: (2014)

Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC‐5, and CFTR
por: Figueira, Miriam F., et al.
Publicado: (2017)

The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells
por: De, Shankhajit, et al.
Publicado: (2014)

The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells
por: Perez Bay, Andres E., et al.
Publicado: (2016)

Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats
por: Jensen, Danny, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_th1obm81kaudcu5ktd15v1qlo0