Design, synthesis, and biological study of 4-[(2-nitroimidazole-1H-alkyloxyl)aniline]-quinazolines as EGFR inhibitors exerting cytotoxicities both under normoxia and hypoxia

PURPOSE: In order to get novel EGFR inhibitors exerting more potency in tumor hypoxia than in normoxia. METHODS: A series of 4-[(2-nitroimidazole-1H-alkyloxyl)aniline]-quinazolines were designed and synthesized, and their in vitro cytotoxicity and EGFR inhibitory activity were evaluated. Molecule do...

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Detalles Bibliográficos
Autores principales: Cheng, Weiyan, Wang, Suhua, Yang, Zhiheng, Tian, Xin, Hu, Yongzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717862/
https://www.ncbi.nlm.nih.gov/pubmed/31695326
http://dx.doi.org/10.2147/DDDT.S209481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717862/
https://www.ncbi.nlm.nih.gov/pubmed/31695326
http://dx.doi.org/10.2147/DDDT.S209481

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