Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice

DNA methylation is generally known to inactivate gene expression. The DNA methyltransferases (DNMTs), DNMT3A and DNMT3B, catalyze somatic cell lineage‐specific DNA methylation, while DNMT3A and DNMT3L catalyze germ cell lineage‐specific DNA methylation. How such lineage‐ and gene‐specific DNA methyl...

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Detalles Bibliográficos
Autores principales: Sasaki, Keisuke, Hara, Satoshi, Yamakami, Reina, Sato, Yusuke, Hasegawa, Saki, Kono, Tomohiro, Morohaku, Kanako, Obata, Yayoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718006/
https://www.ncbi.nlm.nih.gov/pubmed/30834655
http://dx.doi.org/10.1002/mrd.23137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718006/
https://www.ncbi.nlm.nih.gov/pubmed/30834655
http://dx.doi.org/10.1002/mrd.23137

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