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I(K1) Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure via Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats
Intracellular Ca(2+) overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (I(K1)) channel are hallmarks of electrical remodeling in cardiac hypertrophy and heart failure (HF). We hypothesized that enhancement of I(K1) currents is a compensat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718093/ https://www.ncbi.nlm.nih.gov/pubmed/31507422 http://dx.doi.org/10.3389/fphar.2019.00929 |