I(K1) Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure via Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats

Intracellular Ca(2+) overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (I(K1)) channel are hallmarks of electrical remodeling in cardiac hypertrophy and heart failure (HF). We hypothesized that enhancement of I(K1) currents is a compensat...

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Detalles Bibliográficos
Autores principales: Liu, Qing-Hua, Qiao, Xi, Zhang, Li-Jun, Wang, Jin, Zhang, Li, Zhai, Xu-Wen, Ren, Xiao-Ze, Li, Yu, Cao, Xiao-Na, Feng, Qi-Long, Cao, Ji-Min, Wu, Bo-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718093/
https://www.ncbi.nlm.nih.gov/pubmed/31507422
http://dx.doi.org/10.3389/fphar.2019.00929

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