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Increased expression of cathepsin D is required for L1-mediated colon cancer progression

Hyperactivation of Wnt/β-catenin target genes is considered a key step in human colorectal cancer (CRC) development. We previously identified the immunoglobulin-like cell adhesion receptor L1 as a target gene of β-catenin/TCF transactivation that is localized at the invasive edge of CRC tissue. Usin...

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Detalles Bibliográficos
Autores principales: Basu, Sayon, Cheriyamundath, Sanith, Gavert, Nancy, Brabletz, Thomas, Haase, Gal, Ben-Ze’ev, Avri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718269/
https://www.ncbi.nlm.nih.gov/pubmed/31497251
http://dx.doi.org/10.18632/oncotarget.27155