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Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer’s disease on Aβ1-40 peptide early assembly
Inhibition of the initial stages of amyloid-β peptide self-assembly is a key approach in drug development for Alzheimer’s disease, in which soluble and highly neurotoxic low molecular weight oligomers are produced and aggregate in the brain over time. Here we report a high-throughput method based on...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718366/ https://www.ncbi.nlm.nih.gov/pubmed/31407050 http://dx.doi.org/10.1007/s00216-019-02030-7 |