Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylat...

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Detalles Bibliográficos
Autores principales: Gorinski, Nataliya, Bijata, Monika, Prasad, Sonal, Wirth, Alexander, Abdel Galil, Dalia, Zeug, Andre, Bazovkina, Daria, Kondaurova, Elena, Kulikova, Elizabeth, Ilchibaeva, Tatiana, Zareba-Koziol, Monika, Papaleo, Francesco, Scheggia, Diego, Kochlamazashvili, Gaga, Dityatev, Alexander, Smyth, Ian, Krzystyniak, Adam, Wlodarczyk, Jakub, Richter, Diethelm W., Strekalova, Tatyana, Sigrist, Stephan, Bang, Claudia, Hobuß, Lisa, Fiedler, Jan, Thum, Thomas, Naumenko, Vladimir S., Pandey, Ghanshyam, Ponimaskin, Evgeni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718429/
https://www.ncbi.nlm.nih.gov/pubmed/31477731
http://dx.doi.org/10.1038/s41467-019-11876-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718429/
https://www.ncbi.nlm.nih.gov/pubmed/31477731
http://dx.doi.org/10.1038/s41467-019-11876-5

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