Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes

Werner Syndrome (WS) is an adult‐onset segmental progeroid syndrome. Bisulfite pyrosequencing of repetitive DNA families revealed comparable blood DNA methylation levels between classical (18 WRN‐mutant) or atypical WS (3 LMNA‐mutant and 3 POLD1‐mutant) patients and age‐ and sex‐matched controls. WS...

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Detalles Bibliográficos
Autores principales: Maierhofer, Anna, Flunkert, Julia, Oshima, Junko, Martin, George M., Poot, Martin, Nanda, Indrajit, Dittrich, Marcus, Müller, Tobias, Haaf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718529/
https://www.ncbi.nlm.nih.gov/pubmed/31259468
http://dx.doi.org/10.1111/acel.12995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718529/
https://www.ncbi.nlm.nih.gov/pubmed/31259468
http://dx.doi.org/10.1111/acel.12995

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