Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease

Dual‐specificity tyrosine phosphorylation‐regulated kinase‐1A (DYRK1A) is known to phosphorylate the microtubule‐associated tau protein. Overexpression is correlated with tau hyperphosphorylation and neurofibrillary tangle (NFT) formation in Alzheimer's disease (AD). This study assessed the pot...

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Detalles Bibliográficos
Autores principales: Melchior, Benoît, Mittapalli, Gopi Kumar, Lai, Carolyn, Duong‐Polk, Karen, Stewart, Joshua, Güner, Bora, Hofilena, Brian, Tjitro, Amanda, Anderson, Scott D., Herman, David S., Dellamary, Luis, Swearingen, Christopher J., Sunil, K.C., Yazici, Yusuf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718548/
https://www.ncbi.nlm.nih.gov/pubmed/31267651
http://dx.doi.org/10.1111/acel.13000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718548/
https://www.ncbi.nlm.nih.gov/pubmed/31267651
http://dx.doi.org/10.1111/acel.13000

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