MEK1/2 Inhibitors Unlock the Constrained Interferon Response in Macrophages Through IRF1 Signaling

Macrophages are immune sentinels essential for pathogen recognition and immune defense. Nucleic acid-sensing toll-like receptors like TLR7 activate tailored proinflammatory and interferon responses in macrophages. Here we found that TLR7 activation constrained itself and other TLRs from inducing int...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Lei, Ding, Jeak Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718554/
https://www.ncbi.nlm.nih.gov/pubmed/31507609
http://dx.doi.org/10.3389/fimmu.2019.02020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718554/
https://www.ncbi.nlm.nih.gov/pubmed/31507609
http://dx.doi.org/10.3389/fimmu.2019.02020

Ejemplares similares