Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release

Therapeutic manipulation of the BCL-2 family using BH3 mimetics is an emerging paradigm in cancer treatment and immune modulation. For example, peptides mimicking the BIM BH3 helix can directly target the full complement of anti- and pro-apoptotic BCL-2 proteins to trigger apoptosis. This study has...

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Detalles Bibliográficos
Autores principales: Schnorenberg, Mathew R., Bellairs, Joseph A., Samaeekia, Ravand, Acar, Handan, Tirrell, Matthew V., LaBelle, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719084/
https://www.ncbi.nlm.nih.gov/pubmed/31408950
http://dx.doi.org/10.3390/ma12162567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719084/
https://www.ncbi.nlm.nih.gov/pubmed/31408950
http://dx.doi.org/10.3390/ma12162567

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