Cargando…

Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release

Therapeutic manipulation of the BCL-2 family using BH3 mimetics is an emerging paradigm in cancer treatment and immune modulation. For example, peptides mimicking the BIM BH3 helix can directly target the full complement of anti- and pro-apoptotic BCL-2 proteins to trigger apoptosis. This study has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schnorenberg, Mathew R., Bellairs, Joseph A., Samaeekia, Ravand, Acar, Handan, Tirrell, Matthew V., LaBelle, James L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719084/ https://www.ncbi.nlm.nih.gov/pubmed/31408950 http://dx.doi.org/10.3390/ma12162567

Ejemplares similares

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide
por: Hadji, Abbas, et al.
Publicado: (2019)

Synthesis and Purification of Homogeneous Lipid-Based Peptide Nanocarriers by Overcoming Phospholipid Ester Hydrolysis
por: Schnorenberg, Mathew R., et al.
Publicado: (2018)

The Non-Peptidic Part Determines the Internalization Mechanism and Intracellular Trafficking of Peptide Amphiphiles
por: Missirlis, Dimitris, et al.
Publicado: (2013)

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
por: Robin, A Y, et al.
Publicado: (2015)

Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function
por: Hawley, Katrina M., et al.
Publicado: (2022)

Order from Disorder with Intrinsically Disordered Peptide Amphiphiles
por: Jacoby, Guy, et al.
Publicado: (2021)

Self-Assembly of Tunable Intrinsically Disordered Peptide Amphiphiles
por: Ehm, Tamara, et al.
Publicado: (2022)

Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma(☆)
por: Chung, Eun Ji, et al.
Publicado: (2013)

BH3-only proteins, Bmf and Bim, in autophagy
por: Delgado, Monica, et al.
Publicado: (2013)

Gadolinium-Functionalized Peptide Amphiphile Micelles for Multimodal Imaging of Atherosclerotic Lesions
por: Yoo, Sang Pil, et al.
Publicado: (2016)

Intrinsic Fluorescence in Peptide Amphiphile Micelles with Protein-Inspired Phosphate Sensing
por: Fowler, Whitney C.
Publicado: (2022)

Biocompatibility and Characterization of a Peptide Amphiphile Hydrogel for Applications in Peripheral Nerve Regeneration
por: Black, Katie A., et al.
Publicado: (2015)

Role of BH3-only protein Bim in autoimmune and degenerative diseases
por: Bouillet, P, et al.
Publicado: (2003)

Self-assembling amphiphilic peptides†
por: Dehsorkhi, Ashkan, et al.
Publicado: (2014)

Supramolecular Assembly of Peptide Amphiphiles
por: Hendricks, Mark P., et al.
Publicado: (2017)

BH3-Only Protein BIM Mediates Heat Shock-Induced Apoptosis
por: Mahajan, Indra M., et al.
Publicado: (2014)

Peptide Nanovesicles Formed by the Self-Assembly of Branched Amphiphilic Peptides
por: Gudlur, Sushanth, et al.
Publicado: (2012)

Peptide Amphiphiles in Corneal Tissue Engineering
por: Miotto, Martina, et al.
Publicado: (2015)

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
por: McKenzie, Mark D., et al.
Publicado: (2010)

BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency
por: Ren, Decheng, et al.
Publicado: (2014)

The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland
por: Schuler, F, et al.
Publicado: (2016)

Amphiphilic Peptides for Efficient siRNA Delivery
por: Mozaffari, Saghar, et al.
Publicado: (2019)

Characterization of an alternative BAK-binding site for BH3 peptides
por: Ye, Kaiqin, et al.
Publicado: (2020)

Peptides at the Interface: Self-Assembly of Amphiphilic Designer Peptides and Their Membrane Interaction Propensity
por: Kornmueller, Karin, et al.
Publicado: (2016)

Peptide framework for screening the effects of amino acids on assembly
por: Hamsici, Seren, et al.
Publicado: (2022)

Utility of Handheld Ultrasound Performed by Cardiology Fellows in Patients Presenting with Suspected ST-Elevation Myocardial Infarction
por: Samaeekia, Ravand, et al.
Publicado: (2022)

Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf
por: Labi, Verena, et al.
Publicado: (2013)

Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency
por: Ren, Decheng, et al.
Publicado: (2014)

Polymorphism in peptide self-assembly visualized
por: Tirrell, Matthew
Publicado: (2022)

Shape Effects of Peptide Amphiphile Micelles for Targeting Monocytes
por: Joo, Johan, et al.
Publicado: (2018)

Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers
por: Polcyn, Piotr, et al.
Publicado: (2009)

A Peptide Amphiphile Organogelator of Polar Organic Solvents
por: Rouse, Charlotte K., et al.
Publicado: (2017)

Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water
por: Mishra, Abhaya Kumar, et al.
Publicado: (2021)

Precision Medicine to Treat Urothelial Carcinoma—The Way Forward
por: Luceno, Carvy Floyd, et al.
Publicado: (2023)

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
por: Mérino, Delphine, et al.
Publicado: (2009)

The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM)
por: Frank, Daniel O., et al.
Publicado: (2015)

Development of a lytic peptide derived from BH3-only proteins
por: Liu, Q, et al.
Publicado: (2016)

Amphiphilic dendritic peptides: Synthesis and behavior as an organogelator and liquid crystal
por: Gao, Baoxiang, et al.
Publicado: (2011)

Amphiphilic peptides as novel nanomaterials: design, self-assembly and application
por: Qiu, Feng, et al.
Publicado: (2018)

Enhanced translocation of amphiphilic peptides across membranes by transmembrane proteins
por: Bartoš, Ladislav, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j6q829iuhe8k4kfc1ia4iik740