Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1

Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to sorafenib develops frequently and could be mediated by the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin (SIRT)1. We...

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Detalles Bibliográficos
Autores principales: Garten, Antje, Grohmann, Theresa, Kluckova, Katarina, Lavery, Gareth G., Kiess, Wieland, Penke, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719220/
https://www.ncbi.nlm.nih.gov/pubmed/31430957
http://dx.doi.org/10.3390/ijms20164048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719220/
https://www.ncbi.nlm.nih.gov/pubmed/31430957
http://dx.doi.org/10.3390/ijms20164048

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