Implications of non-uniqueness in phylogenetic deconvolution of bulk DNA samples of tumors

BACKGROUND: Tumors exhibit extensive intra-tumor heterogeneity, the presence of groups of cellular populations with distinct sets of somatic mutations. This heterogeneity is the result of an evolutionary process, described by a phylogenetic tree. In addition to enabling clinicians to devise patient-...

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Detalles Bibliográficos
Autores principales: Qi, Yuanyuan, Pradhan, Dikshant, El-Kebir, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719395/
https://www.ncbi.nlm.nih.gov/pubmed/31497065
http://dx.doi.org/10.1186/s13015-019-0155-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719395/
https://www.ncbi.nlm.nih.gov/pubmed/31497065
http://dx.doi.org/10.1186/s13015-019-0155-6

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