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Cardiac contractile dysfunction and protein kinase C–mediated myofilament phosphorylation in disease and aging
Increases in protein kinase C (PKC) are associated with diminished cardiac function, but the contribution of downstream myofilament phosphorylation is debated in human and animal models of heart failure. The current experiments evaluated PKC isoform expression, downstream cardiac troponin I (cTnI) S...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719401/ https://www.ncbi.nlm.nih.gov/pubmed/31366607 http://dx.doi.org/10.1085/jgp.201912353 |