Germinality does not necessarily define mAb expression and thermal stability

The production potential of recombinant monoclonal antibody (mAb) expressing cell lines depends, among other factors, on the intrinsic antibody structure determined by the amino acid sequence. In this study, we investigated the influence of somatic mutations in the V(D)J sequence of four individual,...

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Detalles Bibliográficos
Autores principales: Schwaigerlehner, Linda, Mayrhofer, Patrick, Diem, Matthias, Steinfellner, Willibald, Fenech, Emma, Oostenbrink, Chris, Kunert, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Biotechnological Products and Process Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719414/
https://www.ncbi.nlm.nih.gov/pubmed/31350616
http://dx.doi.org/10.1007/s00253-019-09998-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719414/
https://www.ncbi.nlm.nih.gov/pubmed/31350616
http://dx.doi.org/10.1007/s00253-019-09998-3

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