The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses

The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show that Itch directly limits B cell activity. While Itch-deficient mice displayed normal numbers of preimmune B cell populati...

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Detalles Bibliográficos
Autores principales: Moser, Emily K., Roof, Jennifer, Dybas, Joseph M., Spruce, Lynn A., Seeholzer, Steven H., Cancro, Michael P., Oliver, Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719427/
https://www.ncbi.nlm.nih.gov/pubmed/31311822
http://dx.doi.org/10.1084/jem.20181953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719427/
https://www.ncbi.nlm.nih.gov/pubmed/31311822
http://dx.doi.org/10.1084/jem.20181953

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